About 643 Grand Avenue
Ideally located near Downtown South San Francisco and the cities thriving biotech and life-sciences corridor, 643 Grand Avenue where space, comfort, and a remarkable garden setting come together in the heart of South San Francisco. 643 Grand Avenue offers a spacious and versatile layout with excellent access to major transportation and employment centers. The home features 3 bedrooms and 4 bathrooms, with a private full bathroom for each bedroom. Additional highlights include high ceilings, abundant natural light, hardwood floors, a full basement with ample storage, and a detached 2-car garage equipped with a 220-volt outlet for EV charging. The home also features a water purification system, tankless water heater, and water softener. The quaint lot includes a freshly manicured organic vegetable garden with sunflowers and offers potential for an ADU. Conveniently located near Downtown South San Francisco, Genentech, Caltrain, US-101, and I-280.
Features of 643 Grand Avenue
| MLS® # | ML82059314 |
|---|---|
| Price | $1,248,000 |
| Bedrooms | 3 |
| Bathrooms | 4.00 |
| Full Baths | 4 |
| Square Footage | 1,630 |
| Lot Size | 3,500 |
| Year Built | 1895 |
| Type | Residential |
| Sub-Type | Single Family Residence |
| Status | Active |
Community Information
| Address | 643 Grand Avenue |
|---|---|
| Area | 699 - Not Defined |
| City | South San Francisco |
| County | San Mateo |
| Zip Code | 94080 |
Amenities
| Parking Spaces | 2 |
|---|---|
| # of Garages | 2 |
| Is Waterfront | No |
| Has Pool | No |
Interior
| Heating | Central |
|---|---|
| Cooling | None |
| Has Basement | No |
| Fireplace | No |
| # of Stories | 2 |
Exterior
| Windows | Skylight(s) |
|---|---|
| Roof | Shingle |
| Foundation | Slab |
School Information
| District | South San Francisco Unified |
|---|
Additional Information
| Date Listed | August 27th, 2026 |
|---|---|
| Days on Market | 17 |
| Zoning | RM0000 |
| Foreclosure | No |
| Short Sale | No |
| RE / Bank Owned | No |
Listing Details
| Agent | Jill Penna |
|---|---|
| Office | Christie's International Real Estate Sereno |